Compounds > 6-amino-3-(methoxymethyl)-4-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
Page last updated: 2024-09-28

6-amino-3-(methoxymethyl)-4-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Cross-References

ID SourceID
PubMed CID657572
CHEMBL ID1461824
CHEBI ID115594

Synonyms (13)

Synonym
6-amino-3-(methoxymethyl)-4-(4-methoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
AK-777/11655059
CHEBI:115594
AKOS001615211
6-amino-3-(methoxymethyl)-4-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
HMS2347A14
AKOS016349161
STL320547
CHEMBL1461824
Q27197887
AKOS030505523
sr-01000434796
SR-01000434796-1

Drug Classes (2)

ClassDescription
methoxybenzenesAny aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups.
pyranopyrazoleAn organic heterobicyclic compound whose skeleton consists of a pyran ring which is ortho-fused to a pyrazole ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency11.22020.01846.806014.1254AID624417
phosphopantetheinyl transferaseBacillus subtilisPotency79.43280.141337.9142100.0000AID1490
importin subunit beta-1 isoform 1Homo sapiens (human)Potency0.50125.804836.130665.1308AID540253
snurportin-1Homo sapiens (human)Potency0.50125.804836.130665.1308AID540253
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency0.50125.804816.996225.9290AID540253
gemininHomo sapiens (human)Potency35.48130.004611.374133.4983AID624296
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
recombinase AMycobacterium tuberculosis H37RvEC50 (µMol)24.64000.018023.2882287.6000AID434968; AID435010
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
replicative DNA helicaseMycobacterium tuberculosis H37RvAC5028.97500.057030.7482325.3000AID449749; AID449750
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
tyrphostin a1[no description available]low00methoxybenzenesgeroprotector
anethole trithione[no description available]low00methoxybenzenes
capsaicin[no description available]low00methoxybenzenes;
phenols
dilazep[no description available]low00benzoate ester;
diazepane;
diester;
methoxybenzenes		cardioprotective agent;
platelet aggregation inhibitor;
vasodilator agent
guaifenesin[no description available]low00methoxybenzenes
mefexamide[no description available]low00methoxybenzenes
mescaline[no description available]low00methoxybenzenes;
phenethylamine alkaloid;
primary amino compound		hallucinogen
mofezolac[no description available]low00methoxybenzenes
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone[no description available]low00methoxybenzenes
thonzylamine[no description available]low00methoxybenzenes
trimethoprim[no description available]low00aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
thonzylamine monohydrochloride[no description available]low00methoxybenzenes
mephenoxalone[no description available]low00methoxybenzenes
N-(2-methoxyphenyl)acetamide[no description available]low00acetamides;
methoxybenzenes
creosol[no description available]low00methoxybenzenes;
phenols
2-methyl-4-methoxyaniline[no description available]low00methoxybenzenes
4-methyl anisole[no description available]low00methoxybenzenes
4-anisidine[no description available]low00methoxybenzenes;
primary amino compound;
substituted aniline		genotoxin;
reagent
3,4,5-trimethoxybenzoic acid[no description available]low00benzoic acids;
methoxybenzenes		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
cresidine[no description available]low00methoxybenzenes
mequinol[no description available]low00methoxybenzenes;
phenols		metabolite
1,3-dimethoxybenzene[no description available]low00methoxybenzenes
ethamivan[no description available]low00methoxybenzenes;
phenols
topanol 354[no description available]low00methoxybenzenes;
phenols
phloroglucinol dimethyl ether[no description available]low00methoxybenzenes;
phenols
methoxyhydroxyphenylglycol[no description available]low00methoxybenzenes;
phenols
paeonol[no description available]low00methoxybenzenes;
phenols		metabolite
guaiacol carbonate[no description available]low00methoxybenzenes
4-methoxy-3-phenylenediamine[no description available]low00methoxybenzenes
1,2,3-trimethoxybenzene[no description available]low00methoxybenzenesplant metabolite
propanidid[no description available]low00methoxybenzenes
3-methoxy-4-hydroxyphenylethanol[no description available]low00methoxybenzenes;
phenols
dimethophrine[no description available]low00methoxybenzenes;
phenols
4-vinyl-2,6-dimethoxyphenol[no description available]low00methoxybenzenes;
phenols
arildone[no description available]low00methoxybenzenes
meobentine[no description available]low00methoxybenzenes
4-(4-Methoxyphenyl)-2-butanone[no description available]low00methoxybenzenes
4-ethylguaiacol[no description available]low00methoxybenzenes;
phenols
trithiozine[no description available]low00methoxybenzenes
1,2,4-trimethoxybenzene[no description available]low00methoxybenzenes
g 29505[no description available]low00methoxybenzenes
brodimoprim[no description available]low00aminopyrimidine;
bromobenzenes;
methoxybenzenes		antibacterial drug;
antiinfective agent;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
1,3,5-trimethoxybenzene[no description available]low00methoxybenzenesbiomarker;
human xenobiotic metabolite
2-hydroxy-4-methoxybenzaldehyde[no description available]low00methoxybenzenes;
phenols
4-iodoanisole[no description available]low00methoxybenzenes
moprolol[no description available]low00methoxybenzenes
vanitiolide[no description available]low00methoxybenzenes;
phenols
2,5-di-tert-butyl-4-hydroxyanisole[no description available]low00methoxybenzenes;
phenols
3,5-dimethoxytoluene[no description available]low00methoxybenzenes;
toluenes		fragrance;
plant metabolite
zinniol[no description available]low00methoxybenzenes
sr 95531[no description available]low00methoxybenzenes
2-o-methylpyrogallol[no description available]low00methoxybenzenes;
phenols
cilomilast[no description available]low00methoxybenzenes
4'-demethyldesoxypodophyllotoxin[no description available]low00furonaphthodioxole;
gamma-lactone;
lignan;
methoxybenzenes;
phenols		antineoplastic agent;
antioxidant;
immunosuppressive agent;
plant metabolite
myricanone[no description available]low00aromatic ether;
cyclic ketone;
diarylheptanoid;
methoxybenzenes;
phenols		antineoplastic agent;
plant metabolite
nordihydrocapsaicin[no description available]low00methoxybenzenes;
phenols
isomhpg[no description available]low00methoxybenzenes;
phenols
n-demethyltramadol[no description available]low00methoxybenzenes
5-(3,4,5-trimethoxyphenyl)-3H-1,3,4-oxadiazol-2-one[no description available]low00methoxybenzenes
anthricin[no description available]low00furonaphthodioxole;
gamma-lactone;
lignan;
methoxybenzenes		antineoplastic agent;
apoptosis inducer;
plant metabolite
7-(4-methoxyphenyl)-5-phenyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine[no description available]low00methoxybenzenes
knipholone[no description available]low00aromatic ketone;
dihydroxyanthraquinone;
methoxybenzenes;
methyl ketone;
polyphenol;
resorcinols		antineoplastic agent;
antioxidant;
antiplasmodial drug;
leukotriene antagonist;
metabolite
yatein[no description available]low00benzodioxoles;
butan-4-olide;
lignan;
methoxybenzenes		plant metabolite
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine[no description available]low006-aminopurines;
acetylenic compound;
methoxybenzenes;
monochlorobenzenes;
organofluorine compound		antineoplastic agent;
Hsp90 inhibitor
chavibetol[no description available]low00methoxybenzenes;
phenols
6-amino-4-(2-methoxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00methoxybenzenes;
pyranopyrazole
6-amino-4-[4-(2-amino-2-oxoethoxy)-2-chloro-5-methoxyphenyl]-5-cyano-2-methyl-4H-pyran-3-carboxylic acid methyl ester[no description available]low00methoxybenzenes
N-butyl-N-[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-furancarboxamide[no description available]low00methoxybenzenes
2-(ethylthio)-5-(4-methoxyphenyl)-1,3,4-oxadiazole[no description available]low00methoxybenzenes
5-(4-methoxyphenyl)-7-(4-methylphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine[no description available]low00methoxybenzenes
5-(4-bromophenyl)-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one[no description available]low00methoxybenzenes;
phenols
3-(2-furanylmethyl)-8-(4-methoxyphenyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile[no description available]low00methoxybenzenes
2-methoxy-6-[[(1-propyl-5-benzimidazolyl)amino]methyl]phenol[no description available]low00methoxybenzenes;
phenols
1-(4-Methoxyphenyl)-2-nitroethylene[no description available]low00methoxybenzenes
5-(5-chloro-2-methoxyphenyl)-3H-1,3,4-oxadiazole-2-thione[no description available]low00methoxybenzenes
brd32048[no description available]low00methoxybenzenes;
substituted aniline
2-methoxy-6-[[(1-methyl-2-benzimidazolyl)amino]methyl]phenol[no description available]low00methoxybenzenes;
phenols
4-chloro-N-(3,4,5-trimethoxyphenyl)-5-dithiazolimine[no description available]low00methoxybenzenes;
substituted aniline
(1E,4E)-1,5-bis(4-methoxyphenyl)penta-1,4-dien-3-one[no description available]low00methoxybenzenes
5-amino-3-(4-methoxyphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester[no description available]low00methoxybenzenes;
substituted aniline
(4-methoxyphenyl)-(4-methyl-1-piperazinyl)methanethione[no description available]low00methoxybenzenes
(3-bromo-4-methoxyphenyl)-(4-methyl-1-piperazinyl)methanethione[no description available]low00methoxybenzenes
2-propyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole[no description available]low00methoxybenzenes
1-azepanyl-(4-methoxyphenyl)methanethione[no description available]low00methoxybenzenes
1-[[(1,5-dimethyl-3-pyrazolyl)-oxomethyl]amino]-3-(2-methoxyphenyl)thiourea[no description available]low00methoxybenzenes;
substituted aniline
1-(4-methoxyphenyl)-3-[[oxo(thiophen-2-yl)methyl]amino]thiourea[no description available]low00methoxybenzenes;
substituted aniline
N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine[no description available]low00methoxybenzenes;
substituted aniline
2-(4-methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole[no description available]low00methoxybenzenes
2-(2-methoxyphenoxy)-N-[(2-methoxyphenyl)methyl]acetamide[no description available]low00methoxybenzenes
N4-(4-methoxyphenyl)-1,3,5-triazaspiro[5.5]undeca-1,4-diene-2,4-diamine[no description available]low00methoxybenzenes;
substituted aniline
4-mercapto-5-(4-methoxyphenyl)-2-oxo-1,5-diazaspiro[5.5]undec-3-ene-3-carbonitrile[no description available]low00methoxybenzenes;
substituted aniline
4-[2-(3-methoxyanilino)-4-thiazolyl]phenol[no description available]low00methoxybenzenes;
substituted aniline
N-(3-chloro-4-methoxyphenyl)-4,6-dimethoxy-1,3,5-triazin-2-amine[no description available]low00methoxybenzenes;
substituted aniline
N-[3-cyano-4-(4-methoxyphenyl)-5-methyl-2-thiophenyl]-2-methyl-3-pyrazolecarboxamide[no description available]low00methoxybenzenes
5-[(3,5-dimethyl-4-nitro-1-pyrazolyl)methyl]-N-[(4-methoxyphenyl)methyl]-2-furancarboxamide[no description available]low00methoxybenzenes
N-cyclohexyl-2-[[5-[(4-methoxyphenyl)methyl]-4-methyl-1,2,4-triazol-3-yl]thio]acetamide[no description available]low00methoxybenzenes
2-[[5-[(4-methoxyphenyl)methyl]-1,3,4-oxadiazol-2-yl]thio]-N-(4-methyl-2-thiazolyl)acetamide[no description available]low00methoxybenzenes
6-[[(4,6-dimethyl-2-pyrimidinyl)thio]methyl]-N2-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine[no description available]low00methoxybenzenes;
substituted aniline
3-(4-methoxyphenyl)-2-(4-methoxyphenyl)imino-4-thiazolidinone[no description available]low00methoxybenzenes;
substituted aniline
N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-5-methyl-3-isoxazolecarboxamide[no description available]low00methoxybenzenes
N-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]carbamic acid methyl ester[no description available]low00methoxybenzenes
3-(4-methoxyphenyl)-2,4-dihydrothiazolo[3,2-a][1,3,5]triazin-6-one[no description available]low00methoxybenzenes;
substituted aniline
N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-2-furancarboxamide[no description available]low00methoxybenzenes
zucapsaicin[no description available]low00methoxybenzenes;
phenols
N-[[[2-(2-methoxyphenoxy)-1-oxoethyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00methoxybenzenes
1-(3-methoxyphenyl)-3-[[3-(4-nitro-1-pyrazolyl)-1-oxopropyl]amino]thiourea[no description available]low00methoxybenzenes;
substituted aniline
N-(5-chloro-2-methoxyphenyl)-5-pyridin-4-yl-1,3,4-thiadiazol-2-amine[no description available]low00methoxybenzenes;
substituted aniline
2-[(6-amino-3,5-dicyano-4-thiophen-2-yl-2-pyridinyl)thio]-N-[(2-methoxyphenyl)methyl]acetamide[no description available]low00methoxybenzenes
1-[[(4-bromo-2-methyl-3-pyrazolyl)-oxomethyl]amino]-3-(2-methoxy-5-methylphenyl)thiourea[no description available]low00methoxybenzenes;
substituted aniline
1-[2-(2-chlorophenoxy)ethoxy]-2-methoxy-4-methylbenzene[no description available]low00methoxybenzenes
1-chloro-2-[2-(2-methoxy-4-methylphenoxy)ethoxy]-4-methylbenzene[no description available]low00methoxybenzenes
N-[2-(4-methoxyphenyl)ethyl]-2,3-dihydro-1,4-dioxin-5-carboxamide[no description available]low00methoxybenzenes
2-(4-methoxyphenyl)-5-(2-methylpropylthio)-1,3,4-oxadiazole[no description available]low00methoxybenzenes
1-[2-[[5-(2-methoxyanilino)-1,3,4-thiadiazol-2-yl]thio]-1-oxoethyl]-2-pyrrolidinone[no description available]low00methoxybenzenes;
substituted aniline
4-(2-furanylmethyl)-3-[(3-methoxyphenyl)methyl]-1H-1,2,4-triazole-5-thione[no description available]low00methoxybenzenes
1-(3-methoxyphenyl)-3-(methyl-oxo-phenyl-$l^{6}-sulfanylidene)thiourea[no description available]low00methoxybenzenes;
substituted aniline
2-amino-7-methyl-5-oxo-4-(2,3,4-trimethoxyphenyl)-4,6,7,8-tetrahydro-1-benzopyran-3-carbonitrile[no description available]low00methoxybenzenes
2-amino-7-methyl-5-oxo-4-(2,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydro-1-benzopyran-3-carbonitrile[no description available]low00methoxybenzenes
4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (3-methylcyclohexyl) ester[no description available]low00methoxybenzenes;
phenols
4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (4-methoxyphenyl)methyl ester[no description available]low00methoxybenzenes;
phenols
N'-[(4-methoxyphenyl)methyl]-N-phenylcarbamimidothioic acid (2,5-dioxo-3-pyrrolidinyl) ester[no description available]low00methoxybenzenes
1-ethoxy-3-(2-methoxy-4-prop-2-enylphenoxy)-2-propanol[no description available]low00methoxybenzenes
2-(1-adamantyl)-5-(4-ethoxy-3-methoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-one[no description available]low00methoxybenzenes
2-(3,5-diphenyl-3,4-dihydropyrazol-2-yl)-2-(4-hydroxy-3-methoxyphenyl)acetonitrile[no description available]low00methoxybenzenes;
phenols
5-(4-methoxyanilino)-2-[(3-methylphenoxy)methyl]-4-oxazolecarbonitrile[no description available]low00methoxybenzenes;
substituted aniline
3-(4-methoxyphenyl)-N-methyl-5-(4-methylphenyl)-3,4-dihydropyrazole-2-carbothioamide[no description available]low00methoxybenzenes
1-[1-[2-(4-methoxyphenyl)ethyl]-2,5-dimethyl-3-pyrrolyl]-2-[(1-methyl-5-tetrazolyl)thio]ethanone[no description available]low00methoxybenzenes
7-(2-methoxyphenyl)-5-phenyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine[no description available]low00methoxybenzenes
2-(4-ethoxy-3-methoxyphenyl)-4-mercapto-3-(4-methoxyphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrile[no description available]low00methoxybenzenes;
substituted aniline
2-[[3-(4-methoxyphenyl)-1,2,4-thiadiazol-5-yl]thio]acetic acid ethyl ester[no description available]low00methoxybenzenes
3-(4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-4,5-dihydroisoxazole-5-carboxamide[no description available]low00methoxybenzenes
N-cyclohexyl-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide[no description available]low00methoxybenzenes
N-(2-methoxyethyl)-5-(3-methoxyphenyl)-3-isoxazolecarboxamide[no description available]low00methoxybenzenes
3-(4-methoxyphenyl)-3-(1-pyrrolyl)-N-(2-thiazolyl)propanamide[no description available]low00methoxybenzenes
5-(4-methoxyphenyl)-N-propan-2-yl-3-isoxazolecarboxamide[no description available]low00methoxybenzenes
N-(2-furanylmethyl)-5-(3-methoxyphenyl)-3-isoxazolecarboxamide[no description available]low00methoxybenzenes
3-(3-methoxyphenyl)-N-(3-pyridinyl)-4,5-dihydroisoxazole-5-carboxamide[no description available]low00methoxybenzenes
2-amino-6-ethyl-4-(4-methoxyphenyl)-8-[(4-methoxyphenyl)methyl]-4,5-dihydropyrano[3,2-c]pyridine-3-carbonitrile[no description available]low00methoxybenzenes
2-(2-methoxyphenyl)-1-methyl-3,5-dinitro-2H-pyridine[no description available]low00methoxybenzenes
N4-(2-furanylmethyl)-N2-(3-methoxyphenyl)-5-nitropyrimidine-2,4,6-triamine[no description available]low00methoxybenzenes;
substituted aniline
4-[(4-ethoxy-3-methoxyphenyl)-(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-5-methyl-1,2-dihydropyrazol-3-one[no description available]low00methoxybenzenes
2-[4-(4-methoxyphenyl)-2-thiazolyl]guanidine[no description available]low00methoxybenzenes
1-(Chloroacetyl)-5-[4-(difluoromethoxy)-3-methoxyphenyl]-3-thien-2-yl-4,5-dihydro-1H-pyrazole[no description available]low00methoxybenzenesanticoronaviral agent
N-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)thio]acetamide[no description available]low00methoxybenzenes
3-hydroxy-6-(hydroxymethyl)-2-[(3-methoxyphenyl)-(2-pyridinylamino)methyl]-4-pyranone[no description available]low00methoxybenzenes
1-[[2-(2,4-dichlorophenoxy)-1-oxoethyl]amino]-3-(4-methoxyphenyl)thiourea[no description available]low00methoxybenzenes;
substituted aniline
2-[[6-amino-2-(4-methoxyanilino)-5-nitro-4-pyrimidinyl]amino]ethanol[no description available]low00methoxybenzenes;
substituted aniline
1-amino-3-(4-chloro-2-methoxy-5-methylphenyl)thiourea[no description available]low00methoxybenzenes;
substituted aniline
2-[[2-(4-ethoxy-3-methoxyphenyl)-4-thiazolyl]methylthio]-5-methyl-1,3,4-thiadiazole[no description available]low00methoxybenzenes
6-(4-methoxyphenyl)-8-methyl-4-oxo-6H-pyrimido[2,1-b][1,3]thiazine-2,7-dicarboxylic acid O7-ethyl ester O2-methyl ester[no description available]low00methoxybenzenes
1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]-2-[[5-(4-methoxyanilino)-1,3,4-thiadiazol-2-yl]thio]ethanone[no description available]low00methoxybenzenes;
substituted aniline
6-iodonordihydrocapsaicin[no description available]low00methoxybenzenes;
phenols
pterostilbene[no description available]low00diether;
methoxybenzenes;
stilbenol		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
neuroprotective agent;
neurotransmitter;
plant metabolite;
radical scavenger
4-[5-(4-methoxyphenyl)-3-isoxazolyl]-N-(2-pyridinylmethyl)butanamide[no description available]low00methoxybenzenes
olvanil[no description available]low00methoxybenzenes;
phenols
arvanil[no description available]low00methoxybenzenes;
phenols
1-[2-(4-methoxyphenyl)ethyl]-3,5-dimethyl-4-nitropyrazole[no description available]low00methoxybenzenes
mdl 105725[no description available]low00methoxybenzenes;
phenols
n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride[no description available]low00aromatic ether;
hydrochloride;
methoxybenzenes;
tertiary amino compound		antipsychotic agent;
receptor modulator
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one[no description available]low00methoxybenzenes;
substituted aniline
cardiogenol c[no description available]low00methoxybenzenes;
substituted aniline
3-amino-2-cyano-5-(3-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl ester[no description available]low00methoxybenzenes
N-[5-[2-(2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-2-methylpentanamide[no description available]low00methoxybenzenes;
substituted aniline
N-[5-[2-(5-chloro-2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]hexanamide[no description available]low00methoxybenzenes;
substituted aniline
N-[5-[2-(3-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-3-methylbutanamide[no description available]low00methoxybenzenes;
substituted aniline
N-[5-[2-(2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]heptanamide[no description available]low00methoxybenzenes;
substituted aniline
N-[5-[2-(2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]pentanamide[no description available]low00methoxybenzenes;
substituted aniline
N-[5-[2-(3-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]heptanamide[no description available]low00methoxybenzenes;
substituted aniline
aegeline[no description available]low00methoxybenzenes
siphonazole[no description available]low00methoxybenzenes;
phenols
N-[(2-methoxyphenyl)methyl]-4-[[[2-(4-methyl-1-piperidinyl)-3,4-dioxo-1-cyclobutenyl]amino]methyl]-1-cyclohexanecarboxamide[no description available]low00methoxybenzenes
antrocamphin a[no description available]low00methoxybenzenesanti-inflammatory agent;
metabolite
3-(1,3-benzodioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanone[no description available]low00methoxybenzenes;
phenols
2-[[4-(5-chloro-2-methoxyanilino)-6-(1-piperidinyl)-1,3,5-triazin-2-yl]amino]ethanol[no description available]low00methoxybenzenes;
substituted aniline
2-[[4-(2-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol[no description available]low00methoxybenzenes;
substituted aniline
2-[[4-(3-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol[no description available]low00methoxybenzenes;
substituted aniline
2-[[4-(4-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol[no description available]low00methoxybenzenes;
substituted aniline
n-trans-feruloyloctopamine[no description available]low00methoxybenzenes;
phenols
4-[[4-(2-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]-1-butanol[no description available]low00methoxybenzenes;
substituted aniline
[(1R,5S)-6-azabicyclo[3.2.1]octan-6-yl]-[5-[(4-chloro-2-methoxyphenoxy)methyl]-3-isoxazolyl]methanone[no description available]low00methoxybenzenes
5-[(2-chloro-4-methoxyphenoxy)methyl]-N-[(6-methyl-2-pyridinyl)methyl]-3-isoxazolecarboxamide[no description available]low00methoxybenzenes
1-(3-methoxyphenyl)-2-[4-oxo-6-(trifluoromethyl)-1H-pyrimidin-2-yl]guanidine[no description available]low00methoxybenzenes;
substituted aniline
2-[(4-methoxyphenyl)methylthio]-6-methyl-1H-pyrimidin-4-one[no description available]low00methoxybenzenes
bemotrizinol[no description available]low00methoxybenzenes
2-furancarboxylic acid [4-(6-amino-5-cyano-3-methyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester[no description available]low002-furoate ester;
pyranopyrazole
6-amino-4-(2-ethoxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00aromatic ether;
pyranopyrazole
6-amino-4-(2,3-dimethoxyphenyl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
6-amino-4-(2,5-dimethoxyphenyl)-3-methyl-1-(4-methylphenyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
6-amino-4-(2,4-dimethoxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00dimethoxybenzene;
pyranopyrazole
6-amino-4-[3-ethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00aromatic ether;
pyranopyrazole
6-amino-4-(5-bromo-2-thiophenyl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
thiophenes
cyclopropanecarboxylic acid [5-(6-amino-5-cyano-3-methyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-2-ethoxyphenyl] ester[no description available]low00pyranopyrazole
6-amino-4-(3-chlorophenyl)-3-methyl-1-(phenylmethyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00organochlorine compound;
pyranopyrazole
6-amino-4-(2-methylpropyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
6-amino-4-[3-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00piperazines;
pyranopyrazole
6-amino-4-(2-furanyl)-3-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole
2-[6-amino-5-cyano-4-(4-ethylphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-3-yl]acetic acid methyl ester[no description available]low00benzenes;
pyranopyrazole
6-amino-4-(3-furanyl)-3-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
4-morpholinecarboxylic acid [4-[6-amino-5-cyano-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]phenyl] ester[no description available]low00pyranopyrazole;
ring assembly
2-furancarboxylic acid [4-(6-amino-5-cyano-3-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester[no description available]low002-furoate ester;
pyranopyrazole
4-morpholinecarboxylic acid [3-(6-amino-5-cyano-3-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester[no description available]low00morpholines;
pyranopyrazole
4-morpholinecarboxylic acid [3-(6-amino-5-cyano-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester[no description available]low00morpholines;
pyranopyrazole
6-amino-4-(2-ethoxy-4-hydroxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00aromatic ether;
pyranopyrazole
benzoic acid [4-(6-amino-5-cyano-3-methyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-2-methoxyphenyl] ester[no description available]low00benzoate ester;
pyranopyrazole
2-(6-amino-5-cyano-3-thiophen-2-yl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)benzoic acid[no description available]low00benzoic acids;
pyranopyrazole
6-amino-4-methyl-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
6-amino-4-(3-furanyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole
6-amino-3-methyl-4-(2-methylpropyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole
6-amino-3-(3-methoxyphenyl)-4-(3-thiophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
6-amino-4-(1-cyclohex-2-enyl)-3-thiophen-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole
6-amino-4-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
6-amino-1,3-diphenyl-4-(3,4,5-trimethoxyphenyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile[no description available]low00pyranopyrazole;
ring assembly
ConditionIndicatedRelationship StrengthStudiesTrials
Inflammation0low10
Innate Inflammatory Response0low10
Malaria, Falciparum0low10
Plasmodium falciparum Malaria0low10